Tottenham sit level with Real on seven points in Group H and it would appear a good time to play the European champions, who slipped to a shock La Liga defeat against Girona on Sunday.
Lloris (C), Trippier, Sanchez, Alderweireld, Vertonghen, Davies, Dier, Winks, Eriksen, Dele, Kane
Subs: Vorm, Aurier, Rose, Mousa, Sissoko, Son, Llorente
They will also be without injured trio Gareth Bale, Keylor Navas and Raphael Varane at Wembley but Pochettino is taking nothing for granted.
“We’re not going to watch anything related to Girona. We only analyse the Champions League games and 15 days ago when we played them,” Pochettino said.
“I think Real Madrid have the capacity and quality to change completely in two days.”
Victory, however, would put Spurs not only in a strong position to qualify for the knockout stages but to progress as group winners. After travelling to Dortmund, they finish at home to Apoel Nicosia.
“That’s the last step we need – mental,” Pochettino said. “It’s not about training harder or running more. The last step is mental for us as a club and it’s about working hard to change everything in the future.”